What Medications Could be Useful During a Coronavirus Infection?
SARS-CoV-2 is about 80% identical to SARS-CoV (the coronavirus that caused SARS); and they have similar ways of entering the cell, so they can replicate. Whereas most coronaviruses attach to a peptide (called aminopeptidase N -which breaks down proteins), SARS-CoV and SARS-CoV2 attach to the ACE2 (Angiotensin-converting enzyme-2) receptor. Widespread damage to the inside lining of the vascular system can occur, as the immune system kills these cells in an effort to get rid of the virus. People who are already immunocompromised or have pre-existing health conditions need to take even greater care. Influenza A virus (Flu) strains attach to sialic acids, and not the ACE2 receptor, which also means that different herb and nutrient formulations are required to target different areas of immune function.
What medications are useful during SARS-CoV-2
If infected, people prescribed ACE inhibiters (which increase ACE 2 receptors), are likely to have a higher viral load. It is necessary to address this with your primary care physician, so that blood pressure is regulated at all times! However if you have a fever, paracetamol is the preferred option; as Ibuprofen is likely to boost ACE2 receptors and worsen the disease. Whilst Vit D and A increase ACE2 receptors, the increase is marginal compared to a pharmaceutical. Removal of eg. vit D which is essential in 200 pathways, would be detrimental to the 199 other pathways dependent on that nutrient. Melatonin (naturally higher in young children and pregnant women) is considered to be of use in shutting down the NLRP3 inflammasome (the collection of proteins, receptors, and mediators involved in inflammation. Other drugs include anti-retrovirals (used for HIV), interleukin-1 biologics (used in rheumatoid arthritis, and hydroxychloroquine (an anti-malarial). The vaccine will need to provide a decent antibody response 4-6 mos after vaccination; and at this stage it is unknown whether there will be long term immunity.